353 research outputs found

    DNA insertions distinguish the duplicated renin genes of DBA/2 and M. hortulanus mice

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    In a survey of inbred and wild mouse DNAs for genetic variation at the duplicate renin loci, Ren-1 and Ren-2 , a variant Not I hybridization pattern was observed in the wild mouse M. hortulanus . To determine the basis for this variation, the structure of the M. hortulanus renin loci has been examined in detail and compared to that of the inbred strain DBA/2. Overall, the gross features of structure in this chromosomal region are conserved in both Mus species. In particular, the sequence at the recombination site between the linked Ren-1 and Ren-2 loci was found to be identical in both DBA/2 and M. hortulanus , indicating that the renin gene duplication occurred prior to the divergence of ancestors of these mice. Renin flanking sequences in M. hortulanus , however, were found to lack four DNA insertions totaling approximately 10.5 kb which reside near the DBA/2 loci. The postduplication evolution of the mouse renin genes in thus characterized by a number of insertion and/or deletion events within nearby flanking sequences. Analysis of renin expression showed little or no difference between these mice in steady state renin RNA levels in most tissues examined, suggesting that these insertions do not influence expression at those sites. A notable exception is the adrenal gland, in which DBA/2 and M. hortulanus mice exhibit different patterns of developmentally regulated renin expression.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46988/1/335_2004_Article_BF00570438.pd

    A Holistic Approach to Service Survivability

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    We present SABER (Survivability Architecture: Block, Evade, React), a proposed survivability architecture that blocks, evades and reacts to a variety of attacks by using several security and survivability mechanisms in an automated and coordinated fashion. Contrary to the ad hoc manner in which contemporary survivable systems are built--using isolated, independent security mechanisms such as firewalls, intrusion detection systems and software sandboxes--SABER integrates several different technologies in an attempt to provide a unified framework for responding to the wide range of attacks malicious insiders and outsiders can launch. This coordinated multi-layer approach will be capable of defending against attacks targeted at various levels of the network stack, such as congestion-based DoS attacks, software-based DoS or code-injection attacks, and others. Our fundamental insight is that while multiple lines of defense are useful, most conventional, uncoordinated approaches fail to exploit the full range of available responses to incidents. By coordinating the response, the ability to survive even in the face of successful security breaches increases substantially. We discuss the key components of SABER, how they will be integrated together, and how we can leverage on the promising results of the individual components to improve survivability in a variety of coordinated attack scenarios. SABER is currently in the prototyping stages, with several interesting open research topics

    Machine Learning for the New York City Power Grid

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    Power companies can benefit from the use of knowledge discovery methods and statistical machine learning for preventive maintenance. We introduce a general process for transforming historical electrical grid data into models that aim to predict the risk of failures for components and systems. These models can be used directly by power companies to assist with prioritization of maintenance and repair work. Specialized versions of this process are used to produce (1) feeder failure rankings, (2) cable, joint, terminator, and transformer rankings, (3) feeder Mean Time Between Failure (MTBF) estimates, and (4) manhole events vulnerability rankings. The process in its most general form can handle diverse, noisy, sources that are historical (static), semi-real-time, or real-time, incorporates state-of-the-art machine learning algorithms for prioritization (supervised ranking or MTBF), and includes an evaluation of results via cross-validation and blind test. Above and beyond the ranked lists and MTBF estimates are business management interfaces that allow the prediction capability to be integrated directly into corporate planning and decision support; such interfaces rely on several important properties of our general modeling approach: that machine learning features are meaningful to domain experts, that the processing of data is transparent, and that prediction results are accurate enough to support sound decision making. We discuss the challenges in working with historical electrical grid data that were not designed for predictive purposes. The “rawness” of these data contrasts with the accuracy of the statistical models that can be obtained from the process; these models are sufficiently accurate to assist in maintaining New York City's electrical grid

    S2k guidelines for the diagnosis and treatment of herpes zoster and postherpetic neuralgia

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    The present guidelines are aimed at residents and board-certified specialists in the fields of dermatology, ophthalmology, ENT, pediatrics, neurology, virology, infectious diseases, anesthesiology, general medicine and any other medical specialties involved in the management of patients with herpes zoster. They are also intended as a guide for policymakers and health insurance funds. The guidelines were developed by dermatologists, virologists, ophthalmologists, ENT physicians, neurologists, pediatricians and anesthesiologists/pain specialists using a formal consensus process (S2k). Readers are provided with an overview of the clinical and molecular diagnostic workup, including antigen detection, antibody tests and viral culture. Special diagnostic situations and complicated disease courses are discussed. The authors address general and special aspects of antiviral therapy for herpes zoster and postherpetic neuralgia. Furthermore, the guidelines provide detailed information on pain management including a schematic overview, and they conclude with a discussion of topical treatment options

    Running couplings and triviality of field theories on non-commutative spaces

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    We examine the issue of renormalizability of asymptotically free field theories on non-commutative spaces. As an example, we solve the non-commutative O(N) invariant Gross-Neveu model at large N. On commutative space this is a renormalizable model with non-trivial interactions. On the noncommutative space, if we take the translation invariant ground state, we find that the model is non-renormalizable. Removing the ultraviolet cutoff yields a trivial non-interacting theory.Comment: Latex, 9p, Minor changes, references and clarifications are adde
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